🧫
Sleep and Circadian Dysfunction as Driver of Neurodegeneration
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-sleep-ci
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.906018Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['CACNA1G/CLOCK/GABRA1'], 'diseases': ['Neurodegeneration']} |
| model_system | human |
| summary | # Sleep and Circadian Dysfunction as Driver of Neurodegeneration ## Background and Rationale This clinical study investigates whether sleep and circadian rhythm disruption actively drives neurodegener |
| replication_status | replicated |
| methodology_notes | **Phase 1: Participant Recruitment and Baseline Assessment (Weeks 1-4)** • Recruit 300 cognitively healthy adults aged 50-75 years through community outreach and medical centers • Screen participants |
| primary_outcome | Correlation between SWS reduction rate and amyloid PET SUVr change over 3 years |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.906027'} |
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