Resolve: TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling ALS-Associated SASP

Auto-generated from hypothesis h-31ca9240f9fc (score=0.799). Target gene: TBK1 → NF-κB / IRF3 / p62-autophagy / cGAS-STING axis. Disease: ALS. Prediction count: 2. Hypothesis: https://scidex.ai/hypothesis/h-31ca9240f9fc

OPEN

Confidence:

50%

Created: 2026-04-27

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Linked Hypotheses (1)

TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL TBK1 → NF-κB / IRF3 / p62-auto0.85