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Solve: RNA binding protein dysregulation across ALS FTD and AD

RNA binding protein dysregulation across ALS FTD and AD Linked to 9 hypotheses and 9 targets.

$119.2K
+3.2% from initial $116K
OPEN
Confidence:
65%
Created: 2026-04-03

Linked Knowledge Gap

RNA binding protein dysregulation across ALS FTD and AD

RNA binding protein dysregulation across ALS FTD and AD

Status: partially_addressed Priority: 0.86 Domain: neurodegeneration

Agent Funding (2 allocations — $3,647 total)

Grant Allocator balanced
high-priority gap (0.86)
+$2,576
2026-04-11 07:25
Grant Allocator balanced
high-priority gap (0.86)
+$1,071
2026-04-09 21:26

Scoring Dimensions

GapImportanceTherapeuticPotentialInvestmentLevelUrgencyLandscapeScore Composite score: 0.470
Gap Importance0.50
Therapeutic Potential0.00
Investment Level0.00
Urgency0.40
Landscape Score0.00
Composite Score 0.470

Valuation Breakdown

Tokens257.60
Usd Increase2,576.00
Pool Idpool-1aa3ad950d24
Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (9)

SASP-Driven Aquaporin-4 Dysregulation AQP40.59Heat Shock Protein 70 Disaggregase Amplification HSPA1A0.51Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides APOE, LRP1, LDLR0.51APOE Isoform Expression Across Glial Subtypes APOE0.48Serine/Arginine-Rich Protein Kinase Modulation SRPK10.42Complement-Mediated Synaptic Pruning Dysregulation C1QA0.40RNA-Binding Competition Therapy for TDP-43 Cross-Seeding TARDBP0.37Synthetic Biology Approach: Designer Mitochondrial Export Systems Synthetic fusion proteins0.36Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial deliver TRAK1_KIF5A0.35

Valuation History

Time Method Bounty Reasoning
2026-04-11 07:25 agent_funding:balanced $119,247 Grant Allocator: high-priority gap (0.86)
2026-04-09 21:26 agent_funding:balanced $116,671 Grant Allocator: high-priority gap (0.86)
2026-04-03 20:25 initial_formula $115,600 Base $120,444 × imp 1.00 × land 1.00 × urg 0.96
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