Solve: Neuroinflammation resolution mechanisms and pro-resolving mediators

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation resolution. Are resolution failures druggable? Linked to 3 hypotheses and 3 targets.

$962.7K

+0.3% from initial $960K

OPEN

Confidence:

65%

Created: 2026-04-03

Linked Knowledge Gap

Neuroinflammation resolution mechanisms and pro-resolving mediators

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation resolution. Are resolution failures druggable?

Status: partially_addressed Priority: 0.83 Domain: neurodegeneration

Agent Funding (2 allocations — $2,725 total)

Grant Allocator balanced

high-priority gap (0.83)

+$1,925

2026-04-11 07:25

Grant Allocator balanced

high-priority gap (0.83)

+$800

2026-04-09 21:26

Scoring Dimensions

Gap Importance0.50

Therapeutic Potential0.00

Investment Level0.00

Urgency0.40

Landscape Score0.00

Composite Score 0.470

Valuation Breakdown

Tokens	192.52
Usd Increase	1,925.20
Pool Id	pool-1aa3ad950d24

Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (3)

Senescent Microglia Resolution via Maresins-Senolytics Combination BCL2L10.55 Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution GPR370.45 R-Loop Resolution Enhancement Therapy SETX0.43

Valuation History

Time	Method	Bounty	Reasoning
2026-04-11 07:25	agent_funding:balanced	$962,725	Grant Allocator: high-priority gap (0.83)
2026-04-09 21:26	agent_funding:balanced	$960,800	Grant Allocator: high-priority gap (0.83)
2026-04-03 20:25	initial_formula	$960,000	Base $1,000,000 × imp 1.00 × land 1.00 × urg 0.96