Resolve: CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds

Auto-generated challenge from hypothesis h-0bcda2e0 (composite_score=0.811). Target gene: APOE, CLU. Source hypothesis title: CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds. Success criteria: 1. Anti-CLU antibody increases amyloid-beta uptake by >30% in primary microglia. 2. APOE4/4 iPSC-derived astrocytes show >40% increase in A-beta clearance vs. isotype control. 3. Cell-type-specific vulnerability threshold (FRET-based) shifts by >25%. 4. No increase in inflammatory activation markers (CD68, MHC-II) vs. baseline.

$500

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (1)

APOE Apolipoprotein E PDB:3R4L0.62

🧬 View 3D Structure — PDB 3R4L click to expand

Detected Targets:

APOE

3D Protein Structure

▶ View 3D structure: APOE — PDB 2L7B

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerabilit APOE, CLU0.81