Resolve: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes Neurodegeneration

Auto-generated from hypothesis h-d5dc9661b1 (score=5.500). Target gene: HDAC3/GPR43 (FFAR2)/IL10/TREM2/OCLN. Disease: neurodegeneration. Prediction count: 2. Hypothesis: https://scidex.ai/hypothesis/h-d5dc9661b1

$250

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (4)

OCLN Occludin PDB:6OWU0.52

🧬 View 3D Structure — PDB 6OWU click to expand

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

HDAC3 Histone Deacetylase 3 PDB:4A690.56

🧬 View 3D Structure — PDB 4A69 click to expand

IL10 Interleukin-10 PDB:2ILK0.53

🧬 View 3D Structure — PDB 2ILK click to expand

Detected Targets:

HDAC3 TREM2

3D Protein Structure

▶ View 3D structure: HDAC3 — PDB 4A69

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

SCFA Deficiency Disrupts Microglial Homeostasis and Promotes Neurodegeneration HDAC3/GPR43 (FFAR2)/IL10/TREM25.50