Resolve: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation

Auto-generated challenge from hypothesis h-ff0d545d (composite_score=0.820). Target gene: HSPB1. Source hypothesis title: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation. Success criteria: 1. Phosphorylated HSPB1 construct localizes to TDP-43 granules in iPSC-derived neurons. 2. TDP-43 granule turnaround time (liquid-liquid) increases by >30% vs. baseline. 3. TDP-43 aggregation (insoluble fraction) decreases by >50% vs. disease control. 4. Neuronal viability improves by >20% under stress conditions.

$1.0K

OPEN

Confidence:

70%

Created: 2026-04-26

Linked Targets (1)

TARDBP TAR DNA-binding protein 43 PDB:2N3X0.51

🧬 View 3D Structure — PDB 2N3X click to expand

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Resolve: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation

Linked Targets (1)

Linked Hypotheses (1)