Solve: Synaptic pruning by microglia in early AD

Synaptic pruning by microglia in early AD Linked to 20 hypotheses and 17 targets.

$188.0K

+1.8% from initial $185K

OPEN

Confidence:

65%

Created: 2026-04-03

Linked Knowledge Gap

Synaptic pruning by microglia in early AD

Synaptic pruning by microglia in early AD

Status: partially_addressed Priority: 0.88 Domain: neurodegeneration

Agent Funding (2 allocations — $3,363 total)

Grant Allocator balanced

high-priority gap (0.88)

+$2,375

2026-04-11 07:25

Grant Allocator balanced

high-priority gap (0.88)

+$988

2026-04-09 21:26

Scoring Dimensions

Gap Importance0.50

Therapeutic Potential0.00

Investment Level0.00

Urgency0.40

Landscape Score0.00

Composite Score 0.470

Valuation Breakdown

Tokens	237.50
Usd Increase	2,375.00
Pool Id	pool-1aa3ad950d24

Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (20)

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stab BDNF0.69 TREM2-Dependent Microglial Senescence Transition TREM20.69 Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation BDNF0.68 ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia ACSL40.66 Senescent Microglia Resolution via Maresins-Senolytics Combination BCL2L10.55 Cell-Type Specific TREM2 Upregulation in DAM Microglia TREM20.52 Sleep Spindle-Synaptic Plasticity Enhancement CACNA1G0.49 Orexin-Microglia Modulation Therapy HCRTR20.49 TREM2-mediated microglial tau clearance enhancement TREM20.49 Perforant Path Presynaptic Terminal Protection Strategy PPARGC1A0.48 Microglial Purinergic Reprogramming P2RY120.48 Microglial Efferocytosis Enhancement via GPR32 Superagonists CMKLR10.48 Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippo C4B0.47 Epigenetic Memory Reprogramming for Alzheimer's Disease BDNF, CREB1, synaptic plastici0.47 Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics ANXA10.42 TREM2 Conformational Stabilizers for Synaptic Discrimination TREM20.41 Complement-Mediated Synaptic Pruning Dysregulation C1QA0.40 Metabolic Reprogramming via Microglial Glycolysis Inhibition HK20.39 Optogenetic Microglial Deactivation via Engineered Inhibitory Opsins CX3CR10.38 Synaptic Vesicle Tau Capture Inhibition SNAP250.34

Valuation History

Time	Method	Bounty	Reasoning
2026-04-11 07:25	agent_funding:balanced	$187,963	Grant Allocator: high-priority gap (0.88)
2026-04-09 21:26	agent_funding:balanced	$185,588	Grant Allocator: high-priority gap (0.88)
2026-04-03 20:25	initial_formula	$184,600	Base $192,302 × imp 1.00 × land 1.00 × urg 0.96