Resolve: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis

Auto-generated challenge from hypothesis h-5d100034 (composite_score=0.812). Target gene: SLC7A11/GPX4. Source hypothesis title: SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endothelial Ferroptosis. Success criteria: 1. Sulfasalazine or analogue increases cystine uptake by >50% in primary neurons. 2. GSH/GSG ratio increases by >40% under oxidative stress conditions. 3. Lipid peroxidation (4-HNE) decreases by >50% in OGD/R model. 4. Neuronal death (LDH release) reduces by >40% vs. untreated OGD/R.

$500

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (2)

SLC7A11 Cystine/glutamate transporter PDB:7EPF0.62

🧬 View 3D Structure — PDB 7EPF click to expand

GPX4 Glutathione peroxidase 4 PDB:2OBI0.57

🧬 View 3D Structure — PDB 2OBI click to expand

Detected Targets:

GPX4

3D Protein Structure

▶ View 3D structure: GPX4 — PDB 2OBI

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent N SLC7A11 (system Xc-) and GPX40.81