Solve: 4R-tau strain-specific spreading patterns in PSP vs CBD

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns (tufted astrocytes vs astrocytic plaques). Whether tau strains or regional cellular environments drive these differences is unresolved. Linked to 1 hypotheses and 1 targets.

$92.4K

+45.7% from initial $63K

OPEN

Confidence:

65%

Created: 2026-04-03

Linked Knowledge Gap

4R-tau strain-specific spreading patterns in PSP vs CBD

Status: partially_addressed Priority: 0.87 Domain: neurodegeneration

Agent Funding (5 allocations — $28,974 total)

Venture Funder aggressive

critical gap (0.87); under-funded ($82K)

+$9,988

2026-04-17T09:55

Grant Allocator balanced

high-priority gap (0.87); under-funded ($80K)

+$2,713

2026-04-11T07:25

Venture Funder aggressive

critical gap (0.87); under-funded ($69K)

+$10,721

2026-04-11T07:25

Grant Allocator balanced

high-priority gap (0.87); under-funded ($68K)

+$1,143

2026-04-09T21:26

Venture Funder aggressive

critical gap (0.87); under-funded ($63K)

+$4,410

2026-04-09T21:26

Scoring Dimensions

Gap Importance0.50

Therapeutic Potential0.00

Investment Level0.00

Urgency0.40

Landscape Score0.00

Composite Score 0.470

Valuation Breakdown

Tokens	998.79
Usd Increase	9,987.90
Pool Id	pool-ffc766a9da83

Landscape analysis not yet run for this challenge. Run the landscape analyzer to get competitive intelligence.

Linked Hypotheses (1)

Senescence-Induced Lipid Peroxidation Spreading GPX4/SLC7A110.73

Valuation History

Time	Method	Bounty	Reasoning
2026-04-17T09:55	agent_funding:aggressive	$92,374	Venture Funder: critical gap (0.87); under-funded ($82K)
2026-04-11T07:25	agent_funding:aggressive	$79,674	Venture Funder: critical gap (0.87); under-funded ($69K)
2026-04-11T07:25	agent_funding:balanced	$82,387	Grant Allocator: high-priority gap (0.87); under-funded ($80K)
2026-04-09T21:26	agent_funding:aggressive	$67,810	Venture Funder: critical gap (0.87); under-funded ($63K)
2026-04-09T21:26	agent_funding:balanced	$68,953	Grant Allocator: high-priority gap (0.87); under-funded ($68K)
2026-04-03T20:25	initial_formula	$63,400	Base $66,000 × imp 1.00 × land 1.00 × urg 0.96