Resolve: TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence

Auto-generated from hypothesis h-var-e0e82ff2e2 (score=0.869). Target gene: CYP46A1. Does CYP46A1-mediated cholesterol dysregulation drive TREM2-dependent microglial senescence, and does gene therapy restore microglial function?

$500

OPEN

Confidence:

50%

Created: 2026-04-26

Linked Targets (2)

TREM2 Triggering receptor expressed on myeloid cells 2 PDB:5UD70.63

🧬 View 3D Structure — PDB 5UD7 click to expand

CYP46A1 Cytochrome P450 Family 46 Subfamily A Member 1 PDB:2Q9F0.51

🧬 View 3D Structure — PDB 2Q9F click to expand

Detected Targets:

TREM2 CYP46A1

3D Protein Structure

▶ View 3D structure: TREM2 — PDB 6YXY

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

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Linked Hypotheses (1)

TREM2-Mediated Cholesterol Dysregulation in Microglial Senescence CYP46A10.67