Auto-generated challenge from hypothesis SDA-2026-04-02-gap-tau-prop-20260402003221-H003 (composite_score=0.814). Target gene: CHMP4B. Source hypothesis title: Extracellular Vesicle Biogenesis Modulation. Success criteria: 1. CHMP4B knock-down reduces EV-bound tau by >40% in transwell neuron culture. 2. Conditioned media from CHMP4B-modulated neurons shows >50% reduction in tau seeding in HEK293T biosensor assay. 3. EV size distribution (NTA) remains within 50-200nm range. 4. Neuronal viability is >90% vs. scramble control.