Resolve: PERK Inhibitor GSK2606414 + GADD34 Mimetic Sephin1 Rescues eIF2alpha Stalling in ALS iPSC Motor Neurons

Design and execute the proposed experiment to test the hypothesis: 'H6: Aberrant eIF2alpha Phosphorylation Creates Stalled Translation State'. Primary outcome: p-eIF2alpha/eIF2alpha ratio normalised to <=1.3x isogenic WT; TDP-43 nuclear:cytoplasmic ratio >=2.5. Estimated cost: $67,000; timeline: 16 months.

$5.7K

OPEN

Confidence:

83%

Created: 2026-04-26

Linked Targets (1)

TARDBP TAR DNA-binding protein 43 PDB:2N3X0.51

🧬 View 3D Structure — PDB 2N3X click to expand

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Linked Hypotheses (1)

H6: Aberrant eIF2α Phosphorylation Creates Stalled Translation State EIF2S1, EIF2AK3/PERK, PPP1R15B0.86