Auto-generated challenge from hypothesis h-2dbf5f1f (composite_score=0.806). Target gene: IL6R/IL6. Source hypothesis title: IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microglia Interface. Success criteria: 1. sgp130Fc fusion protein reduces soluble IL-6R trans-signaling by >70% (p-STAT3 read-out). 2. MOG-induced demyelination (cuprizone model) shows >30% increase in MBP+ myelination at week 6. 3. Oligodendrocyte precursor cell (OPC) differentiation increases by >40% in vitro. 4. Motor function (rotarod) improves by >25% vs. vehicle in EAE.