Hypothesis Comparison

graph TD
    A["Gut Microbiome Dysbiosis"]
    B["Reduced SCFA Production"]
    C["Butyrate and Propionate Depletion"]
    D["GPR43 Receptor Downregulation"]
    E["GPR109A Receptor Inactivation"]
    F["Microglial Activation"]
    G["Neuroinflammation"]
    H["Blood-Brain Barrier Disruption"]
    I["Amyloid Beta Accumulation"]
    J["Tau Hyperphosphorylation"]
    K["Synaptic Dysfunction"]
    L["Neuronal Death"]
    M["Probiotic Therapy"]
    N["SCFA Supplementation"]
    O["Cognitive Decline"]
    P["Alzheimer's Disease"]

    A -->|"fiber fermentation loss"| B
    B -->|"metabolite deficiency"| C
    C -->|"ligand depletion"| D
    C -->|"receptor signaling loss"| E
    D -->|"immune dysregulation"| F
    E -->|"anti-inflammatory failure"| F
    F -->|"cytokine release"| G
    G -->|"endothelial damage"| H
    H -->|"protein aggregation"| I
    G -->|"kinase activation"| J
    I -->|"synaptic toxicity"| K
    J -->|"microtubule disruption"| K
    K -->|"apoptosis cascade"| L
    L -->|"network failure"| O
    O -->|"progressive dementia"| P
    M -->|"microbiome restoration"| A
    N -->|"receptor activation"| D

    classDef mechanism fill:#4fc3f7
    classDef pathology fill:#ef5350
    classDef therapy fill:#81c784
    classDef outcome fill:#ffd54f
    classDef genetics fill:#ce93d8

    class A,B,C mechanism
    class D,E genetics
    class F,G,H,I,J pathology
    class K,L,O,P outcome
    class M,N therapy

graph TD
    A["Gut Microbiota"]
    B["SCFA Production"]
    C["Butyrate and Propionate"]
    D["Blood-Brain Barrier Transit"]
    E["Microglial FFAR2/FFAR3 Receptors"]
    F["HDAC Inhibition"]
    G["NF-kappaB Suppression"]
    H["Anti-inflammatory Gene Expression"]
    I["M2 Microglial Polarization"]
    J["Pro-inflammatory Cytokine Reduction"]
    K["Amyloid Clearance Enhancement"]
    L["Neuroinflammation Resolution"]
    M["Synaptic Protection"]
    N["Prebiotic Therapy"]
    O["Probiotic Supplementation"]

    A -->|"metabolite synthesis"| B
    B -->|"fermentation products"| C
    C -->|"systemic circulation"| D
    D -->|"CNS penetration"| E
    E -->|"receptor activation"| F
    F -->|"epigenetic modulation"| G
    G -->|"transcriptional control"| H
    H -->|"phenotype switching"| I
    I -->|"M1 to M2 transition"| J
    J -->|"reduced IL-1beta and TNF-alpha"| K
    K -->|"phagocytic enhancement"| L
    L -->|"tissue homeostasis"| M
    A -.->|"therapeutic targeting"| N
    A -.->|"bacterial modulation"| O

    classDef mechanism fill:#4fc3f7
    classDef pathology fill:#ef5350
    classDef therapy fill:#81c784
    classDef outcome fill:#ffd54f

    class A,B,C,D,E mechanism
    class F,G,H,I mechanism
    class J,K,L pathology
    class M outcome
    class N,O therapy