Hypothesis Comparison

graph TD
    A["AQP4 water channel
polarization in
astrocytic endfeet"]
    B["Bispecific antibody
with AQP4-binding
and antigen domains"]
    C["CSF influx through
perivascular spaces"]
    D["ISF efflux and
waste clearance"]
    E["Amyloid-beta
oligomer targeting"]
    F["Hyperphosphorylated
tau targeting"]
    G["Enhanced glymphatic
flow dynamics"]
    H["AQP4 depolarization
and dysfunction"]
    I["Astrocytic swelling
and inflammation"]
    J["Reduced CSF
pulsatility"]
    K["Pathological protein
accumulation"]
    L["Neuronal toxicity
and cell death"]
    M["Cognitive decline
and neurodegeneration"]
    N["Restored waste
clearance capacity"]
    O["Neuroprotection
and recovery"]

    A -->|"maintains"| C
    A -->|"facilitates"| D
    B -->|"enhances"| A
    B -->|"targets"| E
    B -->|"targets"| F
    C -->|"promotes"| G
    D -->|"removes"| K
    G -->|"increases"| N
    H -->|"impairs"| C
    H -->|"reduces"| D
    I -->|"disrupts"| A
    J -->|"decreases"| G
    K -->|"causes"| L
    L -->|"leads to"| M
    N -->|"prevents"| K
    O -->|"reverses"| M

    classDef normal fill:#4fc3f7
    classDef therapeutic fill:#81c784
    classDef pathology fill:#ef5350
    classDef outcome fill:#ffd54f
    classDef molecular fill:#ce93d8

    class A,C,D,G normal
    class B therapeutic
    class H,I,J,K,L pathology
    class M,N,O outcome
    class E,F molecular

graph TD
    A["FcRn-pHDependent IgG
Neonatal Fc Receptor"]
    B["Endosomal Acidification
pH 6.0-6.5"]
    C["FcRn-IgG Binding
Protected from Lysosomal Degradation"]
    D["FcRn-Mediated Transcytosis
Across Blood-Brain Barrier"]
    E["Bispecific Antibody Design
Dual-Domain Binding"]
    F["Anti-Target Antigen Binding
Therapeutic Effector Function"]
    G["Engineered Fc Domain
Enhanced FcRn Affinity at Acidic pH"]
    H["Reduced Lysosomal Turnover
Extended Serum Half-Life"]
    I["Enhanced Brain Penetration
Therapeutic Antibody Delivery"]
    J["Target Engagement
Amyloid/Tau/Neuroinflammation"]
    K["Focused Ultrasound BBB Opening
Complementary Delivery"]
    L["Combined Delivery Strategy
FcRn Bispecific + FUS"]

    E --> G --> A
    A --> B --> C --> H --> I
    E --> F --> J
    I --> J
    K -.->|"Alternative Route"| I
    L -.->|"Synergistic"| J