In tauopathies, pathological tau alterations may disrupt the antagonistic balance with MAP6, causing excessive stabilization and loss of adaptive plasticity, while in other conditions the relationship may be shifted toward excess lability
Prediction: MAP6 expression levels or post-translational modifications will be altered in tauopathy patient samples as a compensatory response to tau dysfunction
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.70
Evidence
0.65
Novelty
0.65
Feasibility
0.65
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.81
KG Connect
0.30
Score Breakdown
Dimension
Tau/MAP6 antagonism in neurode
Mechanistic
0.700
Evidence
0.650
Novelty
0.650
Feasibility
0.650
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.815
KG Connect
0.304
Evidence
Tau/MAP6 antagonism in neurodegeneration progression