Under neurodegenerative stress, astrocytes upregulate CD38, which triggers Erk MAPK signaling to promote tunneling nanotube (TNT) formation through M-Sec (TNFAIP2) and F-actin remodeling, enabling astrocyte-to-neuron mitochondrial transfer. These transferred mitochondria exhibit enhanced membrane potential and ATP production, restoring neuronal bioenergetics and reducing apoptosis. Disruption of astrocyte CD38 signaling (via CD38 knockout or Erk inhibition) impairs TNT formation and mitochondria
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.76
Evidence
0.72
Novelty
0.68
Feasibility
0.78
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.19
Score Breakdown
Dimension
Astrocyte CD38-erk Mapk signal
Mechanistic
0.760
Evidence
0.720
Novelty
0.680
Feasibility
0.780
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.187
Evidence
Astrocyte CD38-erk Mapk signaling controls mitochondrial tra
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```json
{
"ranked_hypotheses": [],
"knowledge_edges"...