HNRNPA2B1,STAU2,PRMT1,GSK3B,MAP1B,β-actin,axonal transport machinery · als · mechanistic
Composite 0.851
Price $0.73
Evidence For 0
Evidence Against 0
hnRNP A2/B1 is an RNA-binding protein that assembles into axonal RNA granules with Staufen2 (STAU2), mediating the long-range transport of mRNAs (including β-actin, Arp2/3, MAP1B) along microtubules in motor neuron axons. This hypothesis proposes that ALS-linked hnRNP A2/B1 dysfunction (mutations p.P193L, post-translational modification changes) disrupts axonal RNA granule transport, creating a dual defect: (1) insufficient delivery of structural and synaptic protein mRNAs to distal axons, and (
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.73
Evidence
0.75
Novelty
0.82
Feasibility
0.68
Impact
0.78
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.50
Score Breakdown
Dimension
hnRNP A2/B1 Staufen2-Mediated
Mechanistic
0.730
Evidence
0.750
Novelty
0.820
Feasibility
0.680
Impact
0.780
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.500
Evidence
hnRNP A2/B1 Staufen2-Mediated Axonal RNA Granule Transport F