SFPQ,NONO,PSP1,TARDBP,poly(A) machinery,CPSF,PABPN1 · als · mechanistic
Composite 0.864
Price $0.73
Evidence For 0
Evidence Against 0
SFPQ (Splicing Factor Proline-Glutamine Rich) is a non-POU domain octamer binding protein (NONO) family member that functions as an essential splicing factor and RNA processing scaffold. This hypothesis proposes that in ALS motor neurons, TDP-43 cytoplasmic mislocalization causes partial depletion of nuclear SFPQ from its normal genomic loci, triggering expression of a set of germline-era SFPQ-paralog (PSP1/NONO) genes normally silenced in differentiated neurons. These paralogs compete with SFPQ
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.65
Evidence
0.75
Novelty
0.82
Feasibility
0.68
Impact
0.78
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.50
Score Breakdown
Dimension
SFPQ Paralog Displacement Trig
Mechanistic
0.650
Evidence
0.750
Novelty
0.820
Feasibility
0.680
Impact
0.780
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.500
Evidence
SFPQ Paralog Displacement Triggers Cryptic Polyadenylation a