In ALS motor neurons, disease-modified RBM45 hijacks RNA processing condensates through altered LLPS behavior, displacing TDP-43 into pathological aggregates. Similarly, in Frontotemporal dementia (particularly FTD-TDP subtype), FUS (Fused in Sarcoma) - another low-complexity domain RNA-binding protein - undergoes post-translational modifications (phosphorylation, acetylation) that stabilize its condensates at nuclear speckles and stress granules. These dominant FUS condensates may displace TDP-
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.70
Evidence
0.65
Novelty
0.70
Feasibility
0.00
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.37
Score Breakdown
Dimension
FUS Phase Separation Dominance
Mechanistic
0.700
Evidence
0.650
Novelty
0.700
Feasibility
0.000
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.373
Evidence
FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensa