The relative abundance of tau versus MAP6 on individual microtubules determines the balance between stable and labile domains, creating a spatial code for where dynamic remodeling (axon guidance, branching) versus stable support (process integrity) occurs
Prediction: Manipulating the tau:MAP6 expression ratio will shift the entire spectrum of neuronal plasticity phenotypes in a predictable dose-response manner
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.80
Evidence
0.75
Novelty
0.75
Feasibility
0.75
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.40
Reproducible
0.71
KG Connect
0.24
Score Breakdown
Dimension
Tau/MAP6 ratio as a master swi
Mechanistic
0.800
Evidence
0.750
Novelty
0.750
Feasibility
0.750
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.400
Reproducible
0.710
KG Connect
0.235
Evidence
Tau/MAP6 ratio as a master switch for microtubule dynamics p