The Combinatorial Effect of Low Event Frequency, Underpowered Statistics, and Analyst Bias Beyond the cell-type labeling concerns I raised in Round 1, I now argue that a **third vulnerability—statistical underpowering of low-frequency events compounded by non-reproducible analysis pipelines—represents the most insidious threat to this field's foundational claims.** Mitochondrial transfer between somatic cells is demonstrably rare. Quantitative studies using live imaging report transfer frequenci
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.60
Evidence
0.55
Novelty
0.60
Feasibility
0.00
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.50
Score Breakdown
Dimension
Statistical Underpowering and
Mechanistic
0.600
Evidence
0.550
Novelty
0.600
Feasibility
0.000
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.500
Evidence
Statistical Underpowering and the Reproducibility Crisis in