Aberrant MAP6 function may contribute to tau-independent cytoskeletal defects in neurodegeneration, and stabilizing MAP6-microtubule interactions pharmacologically could compensate for Tau pathology
Prediction: Small molecules enhancing MAP6-microtubule binding will ameliorate cytoskeletal defects in tau knockout neurons and improve neuronal survival in amyloid toxicity models
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.55
Evidence
0.50
Novelty
0.50
Feasibility
0.50
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.64
KG Connect
0.30
Score Breakdown
Dimension
MAP6-mediated microtubule stab
Mechanistic
0.550
Evidence
0.500
Novelty
0.500
Feasibility
0.500
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.642
KG Connect
0.304
Evidence
MAP6-mediated microtubule stabilization as therapeutic targe