The ad_genetic_risk_loci dataset identifies PLCG2 rs72824905 as a rare protective AD variant with a strong protective odds-ratio proxy. The notebook's Enrichr and GTEx analysis places PLCG2 in a microglial immune signaling module with actionable phospholipase biology. Hypothesis: partial, pathway-biased PLCG2 activation can increase microglial plaque and debris clearance while avoiding broad inflammatory gain-of-function toxicity.
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.70
Evidence
0.66
Novelty
0.64
Feasibility
0.58
Impact
0.72
Druggability
0.76
Safety
0.46
Competition
0.00
Data
0.78
Reproducible
0.62
KG Connect
0.12
Score Breakdown
Dimension
Calibrated PLCG2 activation ca
Mechanistic
0.700
Evidence
0.660
Novelty
0.640
Feasibility
0.580
Impact
0.720
Druggability
0.760
Safety
0.460
Competition
0.000
Data
0.780
Reproducible
0.620
KG Connect
0.118
Evidence
Calibrated PLCG2 activation can reproduce the protective rs7