PTK2B, BIN1, PICALM, and SORL1 form a trafficking and kinase-linked AD risk cluster in the dataset. The notebook identifies this as a druggable axis because PTK2B is a kinase, BIN1 and PICALM implicate endocytosis, and SORL1 ties the module to APP trafficking. Hypothesis: Pyk2 pathway modulation will normalize tau phosphorylation and endosomal stress in APOE4 or tauopathy human neuronal co-cultures.
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.61
Evidence
0.58
Novelty
0.63
Feasibility
0.60
Impact
0.64
Druggability
0.70
Safety
0.50
Competition
0.00
Data
0.72
Reproducible
0.58
KG Connect
0.50
Score Breakdown
Dimension
Tau-trafficking GWAS loci defi
Mechanistic
0.610
Evidence
0.580
Novelty
0.630
Feasibility
0.600
Impact
0.640
Druggability
0.700
Safety
0.500
Competition
0.000
Data
0.720
Reproducible
0.580
KG Connect
0.500
Evidence
Tau-trafficking GWAS loci define a druggable PTK2B endocytos