TREM2 R47H and ABI3 rs616338 are both AD risk loci linked to microglial response, phagocytosis, and cytoskeletal remodeling. The notebook prioritizes them as a convergent module rather than isolated targets. Hypothesis: restoring TREM2-dependent lipid sensing together with ABI3-linked actin remodeling will rescue plaque engagement and debris clearance more robustly than modulating either locus alone in human iPSC-microglia.
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.68
Evidence
0.62
Novelty
0.61
Feasibility
0.57
Impact
0.70
Druggability
0.62
Safety
0.52
Competition
0.00
Data
0.75
Reproducible
0.60
KG Connect
0.50
Score Breakdown
Dimension
TREM2-ABI3 actin-phagocytosis
Mechanistic
0.680
Evidence
0.620
Novelty
0.610
Feasibility
0.570
Impact
0.700
Druggability
0.620
Safety
0.520
Competition
0.000
Data
0.750
Reproducible
0.600
KG Connect
0.500
Evidence
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD