LAMP2A exists in the lysosomal membrane as both monomers and higher-order oligomers that undergo liquid-liquid phase separation (LLPS) to form membrane microdomains essential for SNCA recognition and translocation into the lysosomal lumen. Recent biophysical studies demonstrate that LAMP2A's cytosolic tail contains an intrinsically disordered region capable of mediating homotypic LLPS, creating lipid-raft-like microdomains enriched in chaperone-HSC70. In A9 dopaminergic neurons (vulnerable), LAM
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.75
Evidence
0.68
Novelty
0.92
Feasibility
0.00
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.19
Score Breakdown
Dimension
LAMP2A Liquid-Liquid Phase Sep
Mechanistic
0.750
Evidence
0.680
Novelty
0.920
Feasibility
0.000
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.187
Evidence
LAMP2A Liquid-Liquid Phase Separation Defects in Dopaminergi