Recent 2024 PD GWAS has identified significant associations in the cathepsin genes CTSO (cathepsin O) and CTSF (cathepsin F), suggesting that non-lysosomal cathepsin variants modify PD risk. CTSO is a cysteine protease with structural similarity to cathepsin B, while CTSF is a lysosomal cysteine protease with overlapping substrate specificity with cathepsin L. We propose that PD risk alleles in CTSO/CTSF create subtle shifts in the intracellular cathepsin network that become catastrophic only in
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.70
Evidence
0.58
Novelty
0.95
Feasibility
0.00
Impact
0.00
Druggability
0.00
Safety
0.00
Competition
0.00
Data
0.00
Reproducible
0.00
KG Connect
0.19
Score Breakdown
Dimension
PD-Associated GWAS Variants in
Mechanistic
0.700
Evidence
0.580
Novelty
0.950
Feasibility
0.000
Impact
0.000
Druggability
0.000
Safety
0.000
Competition
0.000
Data
0.000
Reproducible
0.000
KG Connect
0.187
Evidence
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a