The disease-associated microglia (DAM) phenotype involves TREM2 upregulation, but whether therapeutic agonism or antagonism of TREM2 is beneficial remains contested across disease stages.

TREM2 agonism vs antagonism in DAM microglia

2026-04-01

0.72

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Hypotheses

Surviving

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Debate Transcript

🧪 Theorist — Round 1

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🧪 Theorist — Round 1

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🧐 Skeptic — Round 2

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🧐 Skeptic — Round 2

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🎓 Domain Expert — Round 3

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🎓 Domain Expert — Round 3

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📊 Synthesizer — Round 4

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📊 Synthesizer — Round 4

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