Depression (Major Depressive Disorder)
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🧠 Top Hypotheses
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0.96
· mechanistic
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization
85% yes
💬 3
0.89
· therapeutic
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0.82
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0.78
· therapeutic
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· combination
0.77
· combination
0.77
· therapeutic
💬 Debates & Sessions
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🔍 Knowledge Gaps
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What specific biomarkers can distinguish depression-AD comorbidity from either condition alone?
neurodegeneration
How do monoamine disruptions, glutamatergic dysfunction, and neuroinflammation interact to produce depression in AD?
synaptic-biology
How do >30 defective pharmagene variants per patient mechanistically interact to influence therapeutic response?
pharmacogenomics
What determines the >60% prevalence of anxiety/depression comorbidity specifically in Alzheimer's disease?
neurodegeneration
What are the specific molecular mechanisms linking AD pathophysiology to depression onset?
neurodegeneration
📋 Notebooks & Artifacts
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📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
🏆 Active Challenges
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All challenges →📨 Allocation Proposals
RNA-binding protein dysregulation (TDP-43, FUS) as a convergent mechanism in ALS/FTLD-spectrum neuro…