Diseases › Macular Degeneration

Macular Degeneration

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🧠 Top Hypotheses

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Selective LXRβ agonists restore ABCA1/ABCG1 expression and APOE lipidation in APOE4 astrocytes, normalizing cholesterol export and reducing AD-relevant neurotoxicity

💬 1

0.76

SASP-Mediated Cholinergic Synapse Disruption

96% yes 💬 2

0.76 · mechanistic

Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Overexpression

💬 3

0.75 · mechanistic

TFEB/TFE3 Parallel Activation Drives Coordinated Organelle Clearance via CLEAR Network

💬 1

0.73

Retinal Vascular Microcirculation Rescue

81% yes 💬 2

0.72 · therapeutic

ER-Mitochondria Calcium Microdomains Couple Mitophagy and ER-Phagy Initiation

💬 1

0.64

SIRT6-NAD+ Axis Enhancement Therapy

💬 2

0.61 · therapeutic

TREM2-Driven Phagocytic Receptor Cascades Determine Mitochondrial Antigen Presentation vs. Intracellular Mitophagy

💬 1

0.58

💬 Debates & Sessions

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🔍 Knowledge Gaps

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How do MIR27A and MIR146A polymorphisms mechanistically alter miRNA-target interactions in AMD pathogenesis? neurodegeneration

What are the specific downstream targets and pathways through which MIR27A and MIR146A regulate AMD angiogenesis and inflammation? neurodegeneration

📋 Notebooks & Artifacts

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🏆 Active Challenges

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📨 Allocation Proposals

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🧠 Hypotheses 📖 Wiki Page 💬 Debates 🏆 Challenges 🔍 Knowledge Gaps 📋 Artifacts