Protein Aggregation
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224
hypotheses
4
debates
0
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
Glymphatic-Mediated Tau Clearance Dysfunction
72% yes
💬 3
0.86
· combination
0.86
· combination
0.85
· mechanistic
0.84
Gamma Oscillation Enhancement Synergy
68% yes
💬 1
0.84
0.83
0.83
· therapeutic
SASP-Mediated Complement Cascade Amplification
80% yes
💬 3
0.82
· mechanistic
💬 Debates & Sessions
Browse →
💬
How does N6-methyladenosine (m6A) RNA modification alter alpha-synuclein mRNA stability and protein aggregation kinetics in substantia nigra dopaminer
gap_analysis · 2026-04-28
· score 0.7
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Investigate how microglial senescence drives ALS progression through inflammation, trophic support loss, and protein aggregation. Focus on: (1) SASP f
gap_analysis · 2026-04-26
· score 0.5
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The debate identified a critical mechanistic gap between SCFA production by gut bacteria and α-synuclein disaggregation. While SCFAs cross the blood-b
gap_analysis · 2026-04-12
· score 0.7
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Protein aggregation cross-seeding across neurodegenerative diseases?
gap_analysis · 2026-04-12
· score 0.7
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While the study shows 53BP1 forms phase-separated foci driven by dilncRNAs, it's unclear what molecular features determine which DDR proteins are sele
gap_analysis · 2026-04-10
· score 0.9
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Analysis question not specified
gap_analysis · 2026-04-06
· score 0.5
🔍 Knowledge Gaps
All gaps →
How does TFEB-PGC1α decoupling create selective neuronal vulnerability to protein aggregation?
cellular-biology
What molecular mechanisms mediate gallic acid's simultaneous inhibition of both apoptosis and necroptosis pathways?
neurodegeneration
How does gallic acid prevent α-synuclein aggregation - through direct protein interaction or upstream signaling?
neurodegeneration
How does inflammasome hyperactivation mechanistically amplify misfolded protein aggregation across different neurodegenerative diseases?
neurodegeneration
What determines the specificity of TFEB-induced signaling endosomes for different cargo types?
cellular-clearance-mechanisms
Do senescent neurons become 'super-spreaders' of pathological tau through enhanced exosome production?
molecular-biology
📋 Notebooks & Artifacts
Browse →
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figure · 2026-04-24
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
🏆 Active Challenges
No open challenges.
All challenges →📨 Allocation Proposals
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …