White Matter Degeneration
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16
hypotheses
11
debates
2
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.80
· mechanistic
0.78
· mechanistic
0.77
· mechanistic
0.70
· combination
0.68
0.67
· combination
0.67
· combination
0.66
· combination
0.65
· mechanistic
0.64
· therapeutic
💬 Debates & Sessions
Browse →
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Second debate: Microglial TREM2-SYK Pathway Enhancement
hypothesis_debate · 2026-04-28
· score 0.6
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Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine in Disease-Associated Microglia
hypothesis_debate · 2026-04-27
· score 0.1
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Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidation
hypothesis_debate · 2026-04-27
· score 0.4
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Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability in Disease-Associated Microglia
hypothesis_debate · 2026-04-27
· score 0.5
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Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter Degeneration in Alzheimer's Disease
hypothesis_debate · 2026-04-27
· score 0.5
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Debate: Microglial TREM2 downregulation impairs damage-associated response in late-stage Alzheimer's disease
hypothesis_debate · 2026-04-27
· score 0.2
🔍 Knowledge Gaps
All gaps →
Do white matter changes precede or follow oligodendrocyte transcriptomic dysfunction in aging?
aging-neurobiology
📋 Notebooks & Artifacts
Browse →No artifacts found for this disease yet.
🏆 Active Challenges
Solve: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes Underlies White Matter Degen
$127,900 bounty
Resolve: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease
$5 bounty
All challenges →
📨 Allocation Proposals
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