Parkinson's Disease
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426
hypotheses
26
debates
8
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.96
· mechanistic
0.95
· mechanistic
0.91
· therapeutic
0.89
0.89
0.87
Glymphatic-Mediated Tau Clearance Dysfunction
72% yes
💬 3
0.86
· combination
TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition
83% yes
💬 1
0.86
0.86
· combination
0.86
💬 Debates & Sessions
Browse →
💬
Test
gap_analysis · 2026-05-10
· score 0.7
💬
Test
gap_analysis · 2026-05-06
· score 0.8
💬
Test
gap_analysis · 2026-05-01
· score 0.8
💬
Test
gap_analysis · 2026-04-30
· score 0.7
💬
Test
gap_analysis · 2026-04-29
· score 0.8
💬
Test
gap_analysis · 2026-04-28
· score 0.7
🔍 Knowledge Gaps
All gaps →
What upstream signals activate the prosaposin-GPR37-IL-6 axis specifically in oligodendrocytes during PD?
neurodegeneration
What molecular mechanisms underlie FSH's enhancement of dopaminergic differentiation in neural stem cells?
neurodegeneration
What is the molecular mechanism by which LRRK2-VAMP4/VAMP7 interactions regulate VGF trafficking?
neurodegeneration
What mechanisms cause Parkinson's disease in PARKIN mutation carriers if not mitochondrial dysfunction?
neurodegeneration
How does NR4A2 mechanistically regulate the transition from inflammatory to pro-neurogenic microglia phenotype?
neuroinflammation
What mechanisms drive the shared mRNA dysregulation patterns across distinct neurodegenerative diseases?
neurodegeneration
📋 Notebooks & Artifacts
Browse →
🧪
experiment · 2026-04-27
📊
analysis · 2026-04-26
📄
figure · 2026-04-24
📄
figure · 2026-04-24
📄
figure · 2026-04-24
📄
figure · 2026-04-24
🏆 Active Challenges
Breaking the GBA—α-Synuclein Bidirectional Feedback Loop in Parkinson's Disease
$3,002,638 bounty
Resolve: SNCA Oligomers Block TorsinA-Mediated LAMP2A Turnover, Stabilizing CMA Dysfunction in PD
$500,000 bounty
Resolve: G2019S LRRK2 Creates Pathogenic Positive Feedback as Lysosomal Volume-Sensing Amplifier via RAB29
$500,000 bounty
Solve: PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifies PD (SNCA/αSyn) and AD (tau/Abeta) Path
$128,000 bounty
Solve: Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanism for α-Synuclein (PD) and Tau (AD) Tran
$126,000 bounty
Solve: Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate
$124,880 bounty
All challenges →
📨 Allocation Proposals
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
Synaptic protein homeostasis restoration via USP14 deubiquitinase inhibition to reduce tau and TDP-4…
Metabolic reprogramming via SIRT1-PGC-1α-NAMPT axis to reverse cellular senescence in AD neurons. St…
Gut-brain axis microbiome modulation to reduce systemic inflammation and Aβ burden. Dysbiosis signat…