Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about 3RTAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | 3RTAU |
| Chromosome | 17q21 |
| Subcellular Localization | ** | Axons, neuronal soma | |
| Molecular Weight | 68 kDa |
| Amino Acids | 381 aa |
| Repeat domain structure | Contains R1, R3, and R4 repeats (lacks R2) |
| Microtubule-binding regions | Three hexapeptide motifs (^275KVQIINKK^280, ^306VQIVYKPVDLSKVTSKC^322) |
| N-terminal inserts | Can have 0, 1, or 2 N-terminal inserts (0N, 1N, 2N isoforms) |
| Total length | 352-381 amino acids depending on N-terminal splicing |
| Proline-rich domain | Projecting N-terminal region that modulates interactions |
| Repeat domain | Core microtubule-binding region |
| C-terminal region | Involved in filament formation |
| Phosphorylation sites | Multiple serine, threonine, and tyrosine residues |
| Microtubule assembly | Promotes tubulin polymerization into microtubules |
| Axonal transport | Supports bidirectional transport via motor proteins (kinesins, dyneins) |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["3R-tau protein"] --> B["Microtubule binding"]
A --> C["Tau aggregation"]
B -->|"stabilizes"| D["Microtubule dynamics"]
C -->|"promotes"| E["Neurofibrillary tangles"]
E -->|"causes"| F["Neuronal dysfunction"]
F -->|"leads to"| G["Neurodegeneration"]
A -->|"phosphorylated by"| H["Kinases (GSK-3beta, CDK5)"]
H -->|"increases"| C
I["Tau phosphatases"] -->|"inhibits"| H
C -->|"sequesters"| J["Normal tau function"]
J -->|"impairs"| B
E -->|"triggers"| K["Inflammatory response"]
K -->|"activates"| L["Microglia"]
L -->|"releases"| M["Cytokines"]
M -->|"promotes"| F
G -->|"manifests as"| N["Alzheimer's disease"]
G -->|"manifests as"| O["Frontotemporal dementia"]
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
class A central
class I protective
class C,E,F,G,K,L,M pathological
class H,J regulatory
class N,O disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| proteins-3r-tau | describes | wiki | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning 3RTAU in their description or question text
No additional research found