4RTAU

Understanding Entity Pages

This page aggregates everything SciDEX knows about 4RTAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    A["4R-Tau Protein"]
    B["Microtubule Assembly"]
    C["Axonal Transport"]
    D["Tau Aggregation"]
    E["Neurofibrillary Tangles"]
    F["Neuronal Dysfunction"]
    G["Synaptic Loss"]
    H["Neurodegeneration"]
    I["Alzheimer's Disease"]
    J["Progressive Supranuclear Palsy"]
    K["Corticobasal Degeneration"]
    L["Frontotemporal Dementia"]
    M["Tau Kinases"]
    N["Tau Phosphatases"]
    O["Microglia Activation"]
    P["Neuroinflammation"]

    A -->|"stabilizes"| B
    B -->|"maintains"| C
    M -->|"phosphorylates"| A
    N -->|"dephosphorylates"| A
    A -->|"forms"| D
    D -->|"leads to"| E
    E -->|"causes"| F
    F -->|"results in"| G
    G -->|"promotes"| H
    E -->|"activates"| O
    O -->|"triggers"| P
    P -->|"accelerates"| H
    H -->|"manifests as"| I
    H -->|"manifests as"| J
    H -->|"manifests as"| K
    H -->|"manifests as"| L

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px

    class A central
    class B,C protective
    class D,E,F,G,H,O,P pathological
    class M,N regulatory
    class I,J,K,L disease

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