Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Caffeine | inhibits | compound | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 | 0.695 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna | 0.677 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte | 0.514 | neuroimmunology | Do CXCL10-recruited CD8+ T cells provide |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863] | Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D | Brain research bulletin | 2026 | 0 |
| Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465] | Kwon H, Seo DS, Ahmad Y, Park S, Yoo J, | The Journal of nutritional bio | 2026 | 0 |
| TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794] | Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY, | Molecular psychiatry | 2026 | 0 |
| The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799] | Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK | Brain and behavior | 2026 | 0 |
| Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830] | Kang J, Son Y, Yim Y, Cho H, Kim J et al | J Adv Res | 2026 | 0 |
| Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943] | Xu J, He Z, Pan Y, Cao B, Chen G | Biomater Adv | 2026 | 0 |
| Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914] | Liu R, Wu Z, Yin Y, Song C, Zhang C et a | J Ethnopharmacol | 2026 | 0 |
| Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634] | Yoon S, Chun E, Iqbal H, Kim SH, Kim SY | J Ethnopharmacol | 2026 | 0 |
| Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641] | Zhang K, Zhu S, Xing N, Zhou Z, Chen J e | Br J Pharmacol | 2026 | 0 |
| Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486] | Lahariya R, Anand G, Kumari B, Priyadars | J Neuroimmunol | 2026 | 0 |
| miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168] | Malvandi AM, Gerosa L, Maroni P, Orlando | Neurosci Biobehav Rev | 2026 | 0 |
| Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846] | Piancino MG | Arch Oral Biol | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483] | Alfateh M, Vasconcelos C, Choker AH, Moh | Int J Biol Macromol | 2026 | 0 |
| AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583] | Takahashi K, Kurokawa K, Kawaguchi R, Ta | Neurochem Int | 2026 | 0 |
| Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsatur [PMID:41937329] | Akanchise T, Luo F, Angelov B, Deng Y, A | Adv Healthc Mater | 2026 | 0 |
| Single transient exposure to low-frequency low-intensity electrical stimulation [PMID:41942002] | Marcotto GS, Borghetti M, Bitraj J, Cava | Neuropharmacology | 2026 | 0 |
| Serpina1e mediates the exercise-induced enhancement of hippocampal memory in mal [PMID:41957371] | Kim H, Shin S, Han J, Yun K, Kim JS et a | Nat Commun | 2026 | 0 |
| Ubiquinol Ameliorates Social Disruption-induced Behavioral Changes via Modulatin [PMID:41962635] | Chen CW, Huang BR, Yeh WL, Huang SS, Cha | Behav Brain Res | 2026 | 0 |
| Dietary Advanced Glycation End Products Induced Anxiety- and Depression-like Beh [PMID:41962780] | Ma T, He Z, Yang G, Cai J, Qin LQ et al. | J Nutr Biochem | 2026 | 0 |