gene

aifm3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about aifm3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	AIFM3
Full Name	Apoptosis-Inducing Factor Mitochondria 3
Chromosome	22q13.33
Function	is a mitochondrial protein homologous to AIFM1 and AIFM2, involved in apoptosis and cell death pathways.
Primary Expression	various tissues, with notable expression in: - Heart and skeletal muscle (high mitochondrial content) - Brain regions including [cortex](/brain-region
Subcellular Localization	mitochondria, with potential for translocation under certain conditions
GeneCards	AIFM3
Human Protein Atlas	AIFM3
FAD-binding domain	Contains flavin adenine dinucleotide (FAD)-binding capacity, suggesting oxidoreductase activity [@miranville2004]
NADH-binding domain	Involved in electron transfer reactions
C-terminal domain	Mediates interactions with other proteins and DNA
Apoptosis Effector	Mediates caspase-independent cell death pathways, though its pro-apoptotic activity appears weaker than AIFM1 [@susin2000]
Oxidoreductase	Has NADH oxidase activity, potentially involved in mitochondrial electron transport
Mitochondrial Localization	Primarily localized to mitochondria, with potential for translocation under certain conditions
Associated Diseases	neurodegeneration may lead to therapeutic strategies targeting mito
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AIFM3 — Apoptosis-Inducing Factor Mitochondria 3

gene · 954 words

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Pathway Diagram

graph TD
    A["Regulatory elements"] --> B["aifm3 gene"]
    B --> C["mRNA transcript"]
    C --> D["Protein product"]
    D --> E["Cellular function"]
    E --> F["Disease relevance"]
    B --> G["Variant effects"]
    G --> F
    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    class B gene
    class D protein

Outgoing (1)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:AIFM3	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:AIFM3	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning aifm3 in their description or question text

No additional research found