protein

ALPHACATENIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALPHACATENIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	ALPHACATENIN
Protein Family	Alpha-catenin family, Vinculin family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	100 kDa
UniProt ID	P35221
GeneCards	ALPHACATENIN
Human Protein Atlas	ALPHACATENIN
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ALPHACATENIN — AlphaFold P35221 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Alpha-Catenin Protein

protein · 560 words

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Pathway Diagram

graph TD
    ACTN["ALPHA-CATENIN"]
    BCTN["beta-Catenin"]
    ECAD["E-Cadherin"]
    ACTIN["Actin Cytoskeleton"]
    AJ["Adherens Junctions"]
    BBB["Blood-Brain Barrier"]
    SYN["Synaptic Stability"]
    WNT["Wnt Signaling"]
    GSK3B["GSK-3beta"]
    NEURO["Neurodegeneration"]
    AD["Alzheimer's Disease"]
    INFLAM["Neuroinflammation"]
    APOP["Neuronal Apoptosis"]
    PERM["BBB Permeability"]
    LOSS["Synaptic Loss"]
    PROT["Neuroprotection"]

    ACTN -->|"binds"| BCTN
    ACTN -->|"links to"| ACTIN
    BCTN -->|"forms complex"| ECAD
    ACTN -->|"stabilizes"| AJ
    AJ -->|"maintains"| BBB
    AJ -->|"supports"| SYN
    ACTN -->|"regulates"| WNT
    WNT -->|"inhibits"| GSK3B
    GSK3B -->|"promotes"| APOP
    ACTN -->|"dysfunction leads to"| NEURO
    NEURO -->|"manifests as"| AD
    BBB -->|"breakdown causes"| INFLAM
    SYN -->|"destabilization causes"| LOSS
    INFLAM -->|"accelerates"| NEURO
    LOSS -->|"contributes to"| NEURO
    ACTN -->|"when functional"| PROT

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class ACTN central
    class BBB,SYN,AJ,PROT protective
    class NEURO,INFLAM,APOP,PERM,LOSS pathological
    class WNT,GSK3B,BCTN,ECAD,ACTIN regulatory
    class AD disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ALPHACATENIN in their description or question text

No additional research found