Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AQP4 dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| β-amyloid accumulation | exacerbates | phenotype | 0.85 |
| barrier integrity | disrupts | process | 0.70 |
| microglia pro-inflammatory phenotypes | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Targeting the Mechanistic Link Between AQP4 Dysfunction and | 0.803 | neurodegeneration | Can ferroptosis inhibitors prevent BBB d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085] | Wen H, Zi Y, Liu Z, Bai Y, Lin J et al. | Cell Death Differ | 2026 | 0 |
| Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462] | Tan Y, Ye H, Ge Q, Wang P, Liu Z et al. | J Magn Reson Imaging | 2026 | 0 |
| Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axon [PMID:41967652] | Fang J, Pan X, Chen J | Neurobiol Dis | 2026 | 0 |
| The cornel Iridoid glycoside attenuated brain edema of the cerebral ischemia/rep [PMID:38950636] | Wang Z, Xue F, Zhang J | Fitoterapia | 2024 | 0 |
| Goreisan Prevents Brain Edema after Cerebral Ischemic Stroke by Inhibiting Aquap [PMID:29153303] | Nakano T, Nishigami C, Irie K | J Stroke Cerebrovasc Dis | 2018 | 0 |
| Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquapor [PMID:30093197] | Cheng ZJ, Dai TM, Shen YY | J Stroke Cerebrovasc Dis | 2018 | 0 |
| Curcumin attenuates brain edema in mice with intracerebral hemorrhage through in [PMID:26119880] | Wang BF, Cui ZW, Zhong ZH | Acta Pharmacol Sin | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning AQP4 dysfunction in their description or question text
No additional research found