Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arhgap1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARHGAP1 |
| Full Name | Rho GTPase Activating Protein 1 |
| Chromosome | 11p15.5 |
| Protein Family | Rho GTPase activating protein family |
| Function | The GAP domain catalyzes the intrinsic GTPase activity of Rho GTPases, converting active GTP-bound forms to inactive GDP-bound forms [@arhgap1_function]: |
| Primary Expression | Brain, heart, lung, kidney, testis |
| Subcellular Localization | Protein-protein interactions |
| Molecular Weight | ~22 kDa |
| Amino Acids | 170 aa |
| UniProt ID | Q9UINT8 |
| NCBI Gene ID | 393 |
| Ensembl ID | ENSG00000103540 |
| OMIM | 602737 |
| GeneCards | ARHGAP1 |
| Human Protein Atlas | ARHGAP1 |
| Associated Diseases | Alzheimer's disease through multiple mechanisms [@arhgap1_a |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["arhgap1 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARHGAP1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ARHGAP1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity