gene

arhgef28

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arhgef28: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

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🧬 Gene Info

Gene Symbol	ARHGEF28
Full Name	Rho Guanine Nucleotide Exchange Factor 28
Chromosome	2p16.3
Function	encodes a Rho guanine nucleotide exchange factor (RhoGEF) that activates Rho family GTPases by catalyzing the exchange of GDP for GTP.
Primary Expression	neuronal tissues and plays important roles in synaptic function, neuronal development, and potentially in neurodegenerative disease pathogenesis
UniProt ID	[Q9Y5R5](https://www.uniprot.org/uniprot/Q9Y5R5)
Ensembl ID	ENSG00000136541
GeneCards	ARHGEF28
Human Protein Atlas	ARHGEF28
RhoA Activation	ARHGEF28 activates RhoA, leading to downstream effects on actin cytoskeleton, myosin light chain phosphorylation, and cellular contractility.
Synaptic Signaling	Rho GTPases regulate synaptic structure and function; GEFs like ARHGEF28 link synaptic activity to cytoskeletal changes.
Dendritic Spine Regulation	Rho GTPase signaling controls spine morphology and plasticity through actin dynamics.
Axon Guidance	RhoGEFs direct growth cone collapse and turning in response to guidance cues.
Actin Polymerization	RhoA activation leads to actin stress fiber formation and contractility.
Cell Morphology	Changes in cell shape require coordinated Rho GTPase activation by GEFs.
Associated Diseases	Alzheimer's disease:[@koh2019][@xu2018], ALS:[@rikitake2020], schizophrenia risk
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARHGEF28 — Rho Guanine Nucleotide Exchange Factor 28

gene · 1505 words

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Pathway Diagram

graph TD
    A["Regulatory elements"] --> B["arhgef28 gene"]
    B --> C["mRNA transcript"]
    C --> D["Protein product"]
    D --> E["Cellular function"]
    E --> F["Disease relevance"]
    B --> G["Variant effects"]
    G --> F
    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    class B gene
    class D protein

Outgoing (1)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARHGEF28	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARHGEF28	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found