Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASTROCYTIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CONNEXIN43 | expressed_in | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th | 0.455 | neurodegeneration | Neuroinflammation resolution mechanisms |
| TREM2-Dependent Microglial Surveillance Controls AQP4-Mediat | 0.452 | neuroscience | Circuit-level neural dynamics in neurode |
| Astrocytic Connexin-43 Upregulation Enhances Neuroprotective | 0.450 | neurodegeneration | Mitochondrial transfer between neurons a |
| Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Sign | 0.434 | neuroscience | Circuit-level neural dynamics in neurode |
| Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener | 0.412 | neurodegeneration | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645
molecular biology | 2026-04-13 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-04 | 3 hypotheses Top: 0.506
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772] | Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand | Mol Ther | 2025 | 1 |
| Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035] | Guillén-Yunta M, García-Aldea Á, Valcárc | Neurobiol Dis | 2024 | 1 |
| NAD(+) rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. [PMID:37683629] | Zhan R, Meng X, Tian D, Xu J, Cui H, Yan | Neuron | 2023 | 1 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924] | Cai W, Liu L, Shi X, Liu Y, Wang J, Fang | Circulation | 2023 | 1 |
| Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829] | Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, | Acta Pharmacol Sin | 2023 | 1 |
| Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. [PMID:34199470] | Boal AM, Risner ML, Cooper ML, Wareham L | Cells | 2021 | 1 |
| CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859] | Zhang H, Deng T, Liu R, Ning T, Yang H, | Mol Cancer | 2020 | 1 |
| Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102] | Zhao Y, Bhattacharjee S, Jones BM, Hill | Mol Neurobiol | 2014 | 1 |
| The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875] | Halestrap AP | Mol Aspects Med | 2013 | 1 |
| Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855] | ["Ying H", "Fan H", "Wang Y", "Jiang R", | Advanced science (Weinheim, Ba | 2026 | 0 |
| Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580] | Wen Y, Yuan Y, Zhang H, Liu Y | Molecular medicine reports | 2026 | 0 |
| Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Throug [PMID:41486609] | Yakati V, Rao SS | Biotechnol Bioeng | 2026 | 0 |
| The AP-1 transcription factors differentially regulate Cx43 expression in a ERK1 [PMID:41930557] | Basque A, Izichkis LS, Mellet C, Martin | Reprod Biol | 2026 | 0 |
| Hypoxia Modulates Nanovesicle Phenotype and Angiogenic Function From Human Pluri [PMID:41937255] | Lozano J, Rai A, Phang RJ, Cross J, Lim | Proteomics | 2026 | 0 |
| Bladder under stress: Pathological and adaptive shifts in channel expression. [PMID:41945411] | Swärd K, Andersson KE, Uvelius B | Channels (Austin) | 2026 | 0 |
| Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505] | Chen S, Zhou X, Wang W, Zheng Y, Kang R, | International immunopharmacolo | 2026 | 0 |
| A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157] | ["Zhong R", "Yang H", "Li X", "Wang F", | Journal of inflammation resear | 2026 | 0 |
| Increased Expression of Connexin 43 Promotes Wnt/β-Catenin Signaling and the Pro [PMID:41757775] | Cai S, Yang X, Chen Z, Chen S, Chen L, C | FASEB journal : official publi | 2026 | 0 |
| Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710] | Minogue PJ, Beyer EC, Berthoud VM | International journal of molec | 2026 | 0 |