protein

ATAXIN7

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ATAXIN7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	ATAXIN7
Chromosome	3p12.
Protein Family	Ataxin family, SCA7 proteins
Protein Type	Transferase
Function	is a nuclear protein encoded by the ATXN7 gene that functions as a component of the SPT3/SAGA/SLIK histone acetyltransferase (HAT) complex.
Subcellular Localization	signals (NLS)**: Implicated in nuclear function The polyQ tract normally contai
Molecular Weight	95 kDa
Amino Acids	892 aa
UniProt ID	O75376
GeneCards	ATAXIN7
Human Protein Atlas	ATAXIN7
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATAXIN7 — AlphaFold O75376 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Ataxin-7

protein · 968 words

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Pathway Diagram

graph TD
    ATAXIN7["ATAXIN7
Polyglutamine Protein"]
    PolyQ_expansion["Polyglutamine
Expansion"]
    SCA7["Spinocerebellar
Ataxia Type 7"]
    Transcription_dysreg["Transcriptional
Dysregulation"]
    SAGA_complex["SAGA
Transcriptional Complex"]
    Histone_mod["Histone
Modifications"]
    Protein_aggregates["Protein
Aggregation"]
    Retinal_deg["Retinal
Degeneration"]
    Cerebellar_deg["Cerebellar
Degeneration"]
    Neuronal_death["Neuronal
Cell Death"]
    Oxidative_stress["Oxidative
Stress"]
    Mitochondrial_dysfunction["Mitochondrial
Dysfunction"]
    Neurodegeneration["Neurodegeneration"]
    Autophagy_defects["Autophagy
Defects"]
    UPS_impairment["Ubiquitin-Proteasome
System Impairment"]

    ATAXIN7 -->|"mutated"| PolyQ_expansion
    PolyQ_expansion -->|"causes"| SCA7
    ATAXIN7 -->|"component of"| SAGA_complex
    SAGA_complex -->|"regulates"| Histone_mod
    Histone_mod -->|"controls"| Transcription_dysreg
    PolyQ_expansion -->|"forms"| Protein_aggregates
    Protein_aggregates -->|"impairs"| UPS_impairment
    Protein_aggregates -->|"blocks"| Autophagy_defects
    SCA7 -->|"affects"| Retinal_deg
    SCA7 -->|"affects"| Cerebellar_deg
    Transcription_dysreg -->|"leads to"| Mitochondrial_dysfunction
    Mitochondrial_dysfunction -->|"generates"| Oxidative_stress
    Oxidative_stress -->|"triggers"| Neuronal_death
    Retinal_deg -->|"contributes to"| Neurodegeneration
    Cerebellar_deg -->|"contributes to"| Neurodegeneration
    Neuronal_death -->|"results in"| Neurodegeneration

    classDef central fill:#1a3a4a,stroke:#4fc3f7,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,color:#ffffff

    class ATAXIN7 central
    class PolyQ_expansion,Protein_aggregates,Transcription_dysreg,Retinal_deg,Cerebellar_deg,Neuronal_death,Oxidative_stress,Mitochondrial_dysfunction,UPS_impairment,Autophagy_defects,Neurodegeneration pathological
    class SCA7 disease
    class SAGA_complex,Histone_mod regulatory

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATAXIN7 in their description or question text

No additional research found