Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATN1 |
| Full Name | Atrophin 1 |
| Chromosome | 12p13.31 |
| Function | ATN1 encodes a nuclear protein that functions as a transcriptional co-repressor through multiple mechanisms. |
| Primary Expression | High in brain (cerebellum, basal ganglia), moderate in other tissues |
| Molecular Weight | 128 kDa |
| Amino Acids | 187 aa |
| UniProt ID | O75576 |
| NCBI Gene ID | 4722 |
| Ensembl ID | ENSG00000051617 |
| OMIM | 607462 |
| GeneCards | ATN1 |
| Human Protein Atlas | ATN1 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATN1["ATN1 Gene"]
DRPLA["Dentatorubral-pallidoluysian Atrophy"]
CAG_Expansion["CAG Repeat Expansion"]
Atrophin1["Atrophin-1 Protein"]
Polyglutamine["Polyglutamine Tract"]
Protein_Aggregation["Protein Aggregation"]
Nuclear_Inclusions["Nuclear Inclusions"]
Transcriptional_Dysregulation["Transcriptional Dysregulation"]
Neuronal_Death["Neuronal Death"]
Cerebellum["Cerebellar Degeneration"]
Brainstem["Brainstem Atrophy"]
Cortical_Atrophy["Cortical Atrophy"]
Motor_Symptoms["Motor Symptoms"]
Cognitive_Decline["Cognitive Decline"]
Neurodegeneration["Neurodegeneration"]
ATN1 -->|"encodes"| Atrophin1
ATN1 -->|"mutation leads to"| CAG_Expansion
CAG_Expansion -->|"causes"| DRPLA
CAG_Expansion -->|"produces"| Polyglutamine
Polyglutamine -->|"promotes"| Protein_Aggregation
Protein_Aggregation -->|"forms"| Nuclear_Inclusions
Nuclear_Inclusions -->|"causes"| Transcriptional_Dysregulation
Transcriptional_Dysregulation -->|"leads to"| Neuronal_Death
Neuronal_Death -->|"affects"| Cerebellum
Neuronal_Death -->|"affects"| Brainstem
Neuronal_Death -->|"affects"| Cortical_Atrophy
Cerebellum -->|"causes"| Motor_Symptoms
Cortical_Atrophy -->|"causes"| Cognitive_Decline
Motor_Symptoms -->|"contributes to"| Neurodegeneration
Cognitive_Decline -->|"contributes to"| Neurodegeneration
classDef centralEntity fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff
class ATN1 centralEntity
class CAG_Expansion,Polyglutamine,Protein_Aggregation,Nuclear_Inclusions,Transcriptional_Dysregulation,Neuronal_Death,Cerebellum,Brainstem,Cortical_Atrophy,Motor_Symptoms,Cognitive_Decline,Neurodegeneration pathological
class Atrophin1 regulatory
class DRPLA disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATN1 in their description or question text
No additional research found