gene

ATP1A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP1A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for ATP1A4 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	ATPase Na+/K+ Transporting Subunit Alpha 4
Chromosome	1p13.3
Protein Family	P-type ATPase (Na+/K+ ATPase alpha subunit family)
Function	is a fundamental membrane protein that uses ATP to transport three sodium ions out of the cell and two potassium ions into the cell against their electrochemical gradients.
Primary Expression	male germ cells where it plays a critical role in sperm motility and fertilization
Amino Acids	1029 aa
UniProt ID	Q9HB45
NCBI Gene ID	480
Ensembl ID	ENSG00000197818
OMIM	182342
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATP1A4 — AlphaFold Q9HB45 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATP1A4 Gene

gene · 1244 words

→

Pathway Diagram

graph TD
    ATP1A4["ATP1A4
Na+/K+-ATPase alpha4 subunit"]
    Na_K_pump["Na+/K+-ATPase pump
complex"]
    Ion_homeostasis["Cellular ion
homeostasis"]
    Membrane_potential["Membrane potential
maintenance"]
    Ca_dysregulation["Calcium
dysregulation"]
    Mitochondrial_dysfunction["Mitochondrial
dysfunction"]
    Energy_depletion["ATP depletion"]
    Oxidative_stress["Oxidative stress"]
    Protein_aggregation["Protein
aggregation"]
    Neuronal_excitotoxicity["Neuronal
excitotoxicity"]
    Synaptic_dysfunction["Synaptic
dysfunction"]
    Neuroinflammation["Neuroinflammation"]
    Neurodegeneration["Neurodegeneration"]
    Neuroprotection["Neuroprotective
mechanisms"]
    
    ATP1A4 -->|"encodes"| Na_K_pump
    Na_K_pump -->|"maintains"| Ion_homeostasis
    Na_K_pump -->|"regulates"| Membrane_potential
    Ion_homeostasis -->|"prevents"| Ca_dysregulation
    Membrane_potential -->|"supports"| Neuroprotection
    Ca_dysregulation -->|"triggers"| Mitochondrial_dysfunction
    Mitochondrial_dysfunction -->|"causes"| Energy_depletion
    Energy_depletion -->|"impairs"| Na_K_pump
    Ca_dysregulation -->|"activates"| Neuronal_excitotoxicity
    Mitochondrial_dysfunction -->|"generates"| Oxidative_stress
    Oxidative_stress -->|"promotes"| Protein_aggregation
    Neuronal_excitotoxicity -->|"damages"| Synaptic_dysfunction
    Protein_aggregation -->|"triggers"| Neuroinflammation
    Synaptic_dysfunction -->|"contributes to"| Neurodegeneration
    Neuroinflammation -->|"accelerates"| Neurodegeneration
    
    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    
    class ATP1A4,Na_K_pump central
    class Ion_homeostasis,Membrane_potential,Neuroprotection protective
    class Ca_dysregulation,Mitochondrial_dysfunction,Energy_depletion,Oxidative_stress,Protein_aggregation,Neuronal_excitotoxicity,Synaptic_dysfunction,Neuroinflammation,Neurodegeneration pathological

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP1A4 in their description or question text

No additional research found