gene

ATP2B3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ATP2B3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

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0Incoming

0Experiments

0Debates

Summary

ATP2B3 Gene

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🧬 Gene Info

Gene Symbol	ATP2B3
Full Name	ATPase Plasma Membrane Ca2+ Transporting 3
Chromosome	Xq28
Protein Type	Transporter
Function	ATP2B3 (PMCA3) is a plasma membrane calcium ATPase.
Primary Expression	the brain and testis
UniProt ID	[P32010](https://www.uniprot.org/uniprotkb/P32010/entry)
GeneCards	ATP2B3
Human Protein Atlas	ATP2B3
Associated Diseases	X-linked deafness
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATP2B3 Gene

gene · 658 words

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Pathway Diagram

graph TD
    ATP2B3["ATP2B3 (PMCA3)"]
    Ca_influx["Calcium Influx"]
    Ca_cytosolic["Cytosolic Ca2+ Elevation"]
    Ca_extrusion["Calcium Extrusion"]
    ATP_hydrolysis["ATP Hydrolysis"]
    Mitochondria["Mitochondrial Dysfunction"]
    ER_stress["ER Stress"]
    Calpain["Calpain Activation"]
    Apoptosis["Apoptotic Pathways"]
    Protein_misfolding["Protein Misfolding"]
    Oxidative_stress["Oxidative Stress"]
    Synaptic_dysfunction["Synaptic Dysfunction"]
    Neurodegeneration["Neurodegeneration"]
    Energy_depletion["Energy Depletion"]
    Excitotoxicity["Excitotoxicity"]

    Ca_influx -->|"increases"| Ca_cytosolic
    Excitotoxicity -->|"increases"| Ca_influx
    ATP2B3 -->|"removes"| Ca_cytosolic
    ATP2B3 -->|"requires"| ATP_hydrolysis
    Ca_cytosolic -->|"overloads"| Mitochondria
    Ca_cytosolic -->|"triggers"| ER_stress
    Ca_cytosolic -->|"activates"| Calpain
    Mitochondria -->|"causes"| Energy_depletion
    Mitochondria -->|"generates"| Oxidative_stress
    ER_stress -->|"promotes"| Protein_misfolding
    Calpain -->|"induces"| Apoptosis
    Energy_depletion -->|"impairs"| ATP2B3
    Oxidative_stress -->|"damages"| ATP2B3
    Ca_cytosolic -->|"disrupts"| Synaptic_dysfunction
    Apoptosis -->|"leads to"| Neurodegeneration
    Synaptic_dysfunction -->|"contributes to"| Neurodegeneration

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#ffffff

    class ATP2B3 central
    class Ca_extrusion protective
    class Ca_cytosolic,Mitochondria,ER_stress,Calpain,Apoptosis,Protein_misfolding,Oxidative_stress,Energy_depletion,Excitotoxicity,Ca_influx pathological
    class ATP_hydrolysis regulatory
    class Neurodegeneration,Synaptic_dysfunction disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP2B3 in their description or question text

No additional research found