gene

ATP2B4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ATP2B4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

ATP2B4 Gene

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🧬 Gene Info

Gene Symbol	ATP2B4
Full Name	ATPase Plasma Membrane Ca2+ Transporting 4
Chromosome	1q21.3
Protein Type	Transporter
Function	ATP2B4 (PMCA4) is a plasma membrane calcium ATPase.
UniProt ID	[P55074](https://www.uniprot.org/uniprotkb/P55074/entry)
GeneCards	ATP2B4
Human Protein Atlas	ATP2B4
Associated Diseases	Immune function
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATP2B4 Gene

gene · 637 words

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Pathway Diagram

graph TD
    ATP2B4["ATP2B4 Gene"]
    PMCA4["PMCA4 Protein"]
    CA_HOMEOSTASIS["Calcium Homeostasis"]
    CA_EXTRUSION["Ca2+ Extrusion"]
    CYTOSOLIC_CA["Cytosolic Ca2+"]
    CA_OVERLOAD["Calcium Overload"]
    MITOCHONDRIA["Mitochondrial Dysfunction"]
    ROS["Reactive Oxygen Species"]
    APOPTOSIS["Neuronal Apoptosis"]
    SYNAPTIC_FUNC["Synaptic Function"]
    NEUROPLASTICITY["Neuroplasticity"]
    NEURODEGENERATION["Neurodegeneration"]
    PD["Parkinson's Disease"]
    AD["Alzheimer's Disease"]
    
    ATP2B4 -->|"encodes"| PMCA4
    PMCA4 -->|"maintains"| CA_HOMEOSTASIS
    PMCA4 -->|"promotes"| CA_EXTRUSION
    CA_EXTRUSION -->|"reduces"| CYTOSOLIC_CA
    CYTOSOLIC_CA -->|"when elevated"| CA_OVERLOAD
    CA_OVERLOAD -->|"causes"| MITOCHONDRIA
    MITOCHONDRIA -->|"generates"| ROS
    ROS -->|"triggers"| APOPTOSIS
    CA_HOMEOSTASIS -->|"supports"| SYNAPTIC_FUNC
    SYNAPTIC_FUNC -->|"enables"| NEUROPLASTICITY
    CA_OVERLOAD -->|"impairs"| SYNAPTIC_FUNC
    APOPTOSIS -->|"leads to"| NEURODEGENERATION
    NEURODEGENERATION -->|"manifests as"| PD
    NEURODEGENERATION -->|"manifests as"| AD
    
    classDef central fill:#1a3a4a,stroke:#4fc3f7,color:#ffffff
    classDef protective fill:#1a3a2a,stroke:#81c784,color:#ffffff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,color:#ffffff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,color:#ffffff
    classDef disease fill:#3a2a1a,stroke:#ffa726,color:#ffffff
    
    class ATP2B4 central
    class PMCA4,CA_HOMEOSTASIS,CA_EXTRUSION,SYNAPTIC_FUNC,NEUROPLASTICITY protective
    class CA_OVERLOAD,MITOCHONDRIA,ROS,APOPTOSIS,NEURODEGENERATION pathological
    class CYTOSOLIC_CA regulatory
    class PD,AD disease

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ATP2B4 in their description or question text

No additional research found