Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ATXN10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATXN10 |
| Full Name | Ataxin 10 |
| Aliases | Page for ATXN10 Gene |
| Chromosome | 12q24.31 |
| Protein Family | SCA10 protein family |
| Function | Ataxin 10 is a soluble cytoplasmic protein expressed predominantly in neuronal tissues: |
| Primary Expression | spinal cord |
| Molecular Weight | 47.5 kDa |
| Amino Acids | 476 aa |
| UniProt ID | Q9UQ50 |
| NCBI Gene ID | 4720 |
| Ensembl ID | ENSG00000130638 |
| GeneCards | ATXN10 |
| Human Protein Atlas | ATXN10 |
| Neuronal Survival | Essential for neuronal viability and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ATXN10["ATXN10 gene"]
CGG_expansion["CGG repeat expansion"]
mRNA_processing["mRNA processing defects"]
protein_function["ATXN10 protein dysfunction"]
RNA_toxicity["RNA toxicity"]
splicing_defects["Splicing abnormalities"]
cellular_stress["Cellular stress"]
mitochondrial_dysfunction["Mitochondrial dysfunction"]
protein_aggregation["Protein aggregation"]
cerebellar_atrophy["Cerebellar atrophy"]
purkinje_loss["Purkinje cell loss"]
SCA10["Spinocerebellar ataxia 10"]
neurodegeneration["Neurodegeneration"]
seizures["Epileptic seizures"]
motor_symptoms["Motor dysfunction"]
ATXN10 -->|"mutation"| CGG_expansion
CGG_expansion -->|"disrupts"| mRNA_processing
CGG_expansion -->|"causes"| RNA_toxicity
mRNA_processing -->|"impairs"| protein_function
RNA_toxicity -->|"triggers"| splicing_defects
protein_function -->|"leads to"| cellular_stress
splicing_defects -->|"causes"| mitochondrial_dysfunction
cellular_stress -->|"promotes"| protein_aggregation
mitochondrial_dysfunction -->|"induces"| purkinje_loss
protein_aggregation -->|"contributes to"| cerebellar_atrophy
purkinje_loss -->|"results in"| SCA10
cerebellar_atrophy -->|"causes"| neurodegeneration
SCA10 -->|"manifests as"| seizures
SCA10 -->|"manifests as"| motor_symptoms
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
class ATXN10 central
class CGG_expansion,mRNA_processing,RNA_toxicity,splicing_defects,cellular_stress,mitochondrial_dysfunction,protein_aggregation,cerebellar_atrophy,purkinje_loss,protein_function pathological
class SCA10,neurodegeneration,seizures,motor_symptoms disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ATXN10 in their description or question text
No additional research found